Go to http://www.macromedia.com/support/documentation/en/flashplayer/help/settings_manager04a.html
Verify that the local drives are available under ‘Always trust files in these locations:'. If not, then click Edit locations...
Click Add location...
Click Browse for folder…
Select the C drive.
Click Confirm.
Notice that the C drive is now listed under the trusted locations.
Follow the same steps for other locations.